SCHEMBL19913151

SCHEMBL19913151

Cc1ccc2c3ccc(C(F)(F)F)cc3n(-c3cc(C#N)cc(-n4c5cc(C)ccc5c5ccc(C(F)(F)F)cc54)c3-c3ccncc3)c2c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 5/20 0.35
GRM5 P41594 3/20 0.34
PTGDR2 Q9Y5Y4 1/20 0.34
ELANE P08246 1/20 0.33
MAT2A P31153 5/20 0.33
MAPK14 Q16539 2/20 0.33
RIPK3 Q9Y572 1/20 0.33
CYP3A4 P08684 1/20 0.32
CYP3A5 P20815 1/20 0.32
GABRP O00591 1/20 0.32
GABRD O14764 1/20 0.32
GABRA1 P14867 1/20 0.32
GABRB1 P18505 1/20 0.32
GABRG2 P18507 1/20 0.32
GABRB3 P28472 1/20 0.32
GABRA5 P31644 1/20 0.32
GABRA3 P34903 1/20 0.32
GABRA2 P47869 1/20 0.32
GABRB2 P47870 1/20 0.32
GABRA4 P48169 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19913146 0.95 KIF11 (0.40) KIF11GRM5PTGDR2ELANEMAT2A
SCHEMBL19919749 0.93 KIF11 (0.40) KIF11MAT2AMAPK14RIPK3CYP3A4
SCHEMBL19913138 0.90 MAPK14 (0.36) GRM5MAPK14
SCHEMBL19913157 0.89 KIF11 (0.37) KIF11PTGDR2ELANEMAT2AMAPK14
SCHEMBL19908947 0.88 KIF11 (0.42) KIF11MAT2AMAPK14RIPK3CYP3A4
SCHEMBL19913149 0.87 KIF11 (0.36) KIF11GRM5PTGDR2ELANEMAT2A
SCHEMBL19913167 0.85 CYP2C9 (0.32) KIF11PTGDR2ELANE
SCHEMBL19913163 0.85 RXRA (0.36) KIF11GRM5MAPK14RIPK3GABRP
SCHEMBL19913140 0.84 MAPK14 (0.37) GRM5ELANEMAPK14
SCHEMBL19903637 0.84 RXRA (0.37) KIF11GRM5GABRPGABRDGABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180062085-A1 ORGANIC MOLECULES FOR USE IN OPTOELECTRONIC DEVICES SAMSUNG DISPLAY CO., LTD. (KR) 2018-03-01 US disclosed