Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7641978 | 0.80 | CNR1 (0.41) | CNR1MTNR1AMTNR1BALDH1A1KDM4E | |
| SCHEMBL4702861 | 0.79 | ALDH1A1 (0.47) | ALDH1A1KDM4EPOLBSMN1; SMN2MEN1 | |
| SCHEMBL14141265 | 0.79 | NPC1 (0.59) | CNR1ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL10593239 | 0.76 | MAPT (0.64) | ALDH1A1KDM4ELMNAMAPTHPGD | |
| SCHEMBL3769977 | 0.76 | CA1 (0.47) | MEN1KMT2A | |
| SCHEMBL184041 | 0.75 | TRPV1 (0.59) | CNR1LMNAMAPTMEN1KMT2A | |
| SCHEMBL1968355 | 0.74 | CA12 (0.66) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL9128943 | 0.74 | MTNR1A (0.53) | MTNR1AMTNR1BALDH1A1KDM4EMAPT | |
| SCHEMBL5148312 | 0.74 | TRPV1 (0.48) | ALDH1A1MAPTPOLBSMN1; SMN2MEN1 | |
| SCHEMBL6433557 | 0.73 | KDM4E (0.61) | ALDH1A1KDM4EMAPTPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2374796-B1 | 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, its salts, solvates or hydrates and its use for the treatment of CNS disorderes | ARENA PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |