Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | KIF11 | P52732 | 5/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20887126 | 0.98 | HSD17B10 (0.50) | HSD17B10LMNASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL29056463 | 0.95 | KIF11 (0.49) | HSD17B10LMNASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL28336625 | 0.85 | HTR6 (0.58) | HSD17B10LMNAALDH1A1HPGDTSHR | |
| SCHEMBL146694 | 0.84 | KDM4E (0.53) | HSD17B10LMNASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL3876761 | 0.75 | LMNA (0.45) | HSD17B10LMNASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL147379 | 0.74 | KIF11 (0.42) | HSD17B10LMNAALDH1A1HPGDTSHR | |
| SCHEMBL27568785 | 0.74 | KIF11 (0.52) | HSD17B10LMNASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL11181361 | 0.73 | PSMB8 (0.47) | HSD17B10ALDH1A1KDM4EMAPK1KEAP1 | |
| SCHEMBL10613479 | 0.73 | HSD17B10 (0.63) | HSD17B10LMNASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL30572810 | 0.72 | KIF11 (0.50) | HSD17B10LMNAALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108349961-B | Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents | 西奈山伊坎医学院 | 2022-02-18 | — | — | CN | disclosed |
| CN-104903308-B | Piperidyl carbazoles as antimalarial | 默克专利股份有限公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-104903308-B | Piperidyl carbazoles as antimalarial | 默克专利股份有限公司 | 2018-06-08 | — | — | CN | disclosed |
| US-9908863-B2 | Piperidinylcarbazoles | MERCK PATENT GMBH (DE) | 2018-03-06 | — | — | US | disclosed |
| CN-104903308-A | Piperidinylcarbazole as antimalarial | MERCK PATENT GMBH | 2015-09-09 | — | — | CN | disclosed |
| CN-104903308-A | Piperidinylcarbazole as antimalarial | MERCK PATENT GMBH | 2015-09-09 | — | — | CN | disclosed |