Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 8/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.34 |
| ▸ | ABL1 | P00519 | 7/20 | 0.34 |
| ▸ | EGFR | P00533 | 7/20 | 0.34 |
| ▸ | HCK | P08631 | 7/20 | 0.34 |
| ▸ | SRC | P12931 | 7/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.34 |
| ▸ | MTOR | P42345 | 7/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 7/20 | 0.34 |
| ▸ | PRKDC | P78527 | 7/20 | 0.34 |
| ▸ | PDE9A | O76083 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 5/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21138767 | 0.76 | KDR (0.53) | KDRPIK3CDABL1EGFRHCK | |
| SCHEMBL21057281 | 0.74 | KDR (0.43) | NR3C1KDRPIK3CDABL1EGFR | |
| SCHEMBL18642033 | 0.72 | JAK2 (0.42) | KDRPIK3CDABL1EGFRHCK | |
| SCHEMBL2077062 | 0.69 | PDE9A (0.54) | PDE9AALDH1A1 | |
| SCHEMBL29113651 | 0.68 | PDE9A (0.39) | NR3C1PDE9ARET | |
| SCHEMBL29113643 | 0.68 | NR3C1 (0.47) | NR3C1KDRPIK3CDPIK3CAPIK3CG | |
| SCHEMBL2078528 | 0.67 | ALDH1A1 (0.54) | PDE9AALDH1A1 | |
| SCHEMBL25065700 | 0.67 | ABL1 (0.39) | KDRABL1EGFRSRCALDH1A1 | |
| SCHEMBL21159325 | 0.67 | ABL1 (0.41) | ADAMTS5NR3C1KDRPIK3CDABL1 | |
| SCHEMBL22086527 | 0.67 | ABL1 (0.39) | KDRABL1EGFRSRCALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3505171-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2019-07-03 | — | — | EP | disclosed |
| EP-3505171-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2019-07-03 | — | — | EP | disclosed |
| US-20190185479-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2019-06-20 | — | — | US | disclosed |
| US-20190185479-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2019-06-20 | — | — | US | disclosed |
| WO-2018038265-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | 田辺三菱製薬株式会社 | 2018-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190185479-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | PDE7B, PDE3A, PDE7A | ADAMTS5 1261/4885NR3C1 1835/4885KDR 4093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.