Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 10/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917669 | 0.88 | TRPA1 (0.43) | TRPA1 | |
| SCHEMBL19917732 | 0.88 | TRPA1 (0.54) | TRPA1RORCALDH1A1 | |
| SCHEMBL19917714 | 0.84 | TRPA1 (0.42) | TRPA1ALDH1A1GAA | |
| SCHEMBL16894121 | 0.83 | TRPA1 (0.59) | TRPA1RORCALDH1A1 | |
| SCHEMBL19917672 | 0.83 | CASR (0.42) | TRPA1 | |
| SCHEMBL19917755 | 0.83 | TRPA1 (0.47) | TRPA1 | |
| SCHEMBL19917691 | 0.81 | KDM1A (0.45) | TRPA1KDM1AHDAC1RORCALDH1A1 | |
| SCHEMBL19917744 | 0.81 | TRPA1 (0.45) | TRPA1 | |
| SCHEMBL19917693 | 0.80 | CASR (0.56) | TRPA1ALDH1A1GAA | |
| SCHEMBL19917782 | 0.80 | TRPA1 (0.51) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |