Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 8/20 | 0.56 |
| ▸ | PPARA | Q07869 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917672 | 0.90 | CASR (0.42) | CASRPPARAKMT2AMEN1TRPA1 | |
| SCHEMBL16894229 | 0.84 | CASR (0.57) | CASRTRPA1 | |
| SCHEMBL19917714 | 0.84 | TRPA1 (0.42) | CASRALDH1A1GAATRPA1 | |
| SCHEMBL19917732 | 0.84 | TRPA1 (0.54) | CASRKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL19917669 | 0.83 | TRPA1 (0.43) | PPARATRPA1 | |
| SCHEMBL19917692 | 0.82 | CASR (0.57) | CASRPPARAKMT2APPARDMEN1 | |
| SCHEMBL16894169 | 0.81 | ALDH1A1 (0.53) | CASRKMT2AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL19917690 | 0.80 | TRPA1 (0.43) | ALDH1A1GAATRPA1 | |
| SCHEMBL19917764 | 0.80 | CASR (0.39) | CASRPPARAKMT2AMEN1TRPA1 | |
| SCHEMBL19917755 | 0.79 | TRPA1 (0.47) | KMT2ATRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |