Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 7/20 | 0.40 |
| ▸ | PTGES | O14684 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917764 | 0.90 | CASR (0.39) | CASRTRPA1PTGESMEN1KMT2A | |
| SCHEMBL19917693 | 0.90 | CASR (0.56) | CASRTRPA1MEN1KMT2APPARA | |
| SCHEMBL19917688 | 0.88 | CASR (0.38) | CASRTRPA1NPC1RAB9APPARA | |
| SCHEMBL19917749 | 0.87 | TRPA1 (0.54) | TRPA1PTGES | |
| SCHEMBL19917732 | 0.86 | TRPA1 (0.54) | CASRTRPA1MEN1KMT2A | |
| SCHEMBL19917669 | 0.85 | TRPA1 (0.43) | TRPA1NPC1RAB9AHPGDPPARA | |
| SCHEMBL19917755 | 0.85 | TRPA1 (0.47) | TRPA1KMT2A | |
| SCHEMBL19917690 | 0.83 | TRPA1 (0.43) | TRPA1 | |
| SCHEMBL16894112 | 0.83 | TRPA1 (0.56) | TRPA1PTGER1 | |
| SCHEMBL19917714 | 0.82 | TRPA1 (0.42) | CASRTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |