Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | BMP1 | P13497 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917714 | 0.91 | TRPA1 (0.42) | TRPA1RXRARXRBRXRGTP53 | |
| SCHEMBL19917735 | 0.91 | TRPA1 (0.40) | TRPA1RXRARXRBRXRGTP53 | |
| SCHEMBL19917762 | 0.87 | NPC1 (0.46) | HPGDMEN1KMT2A | |
| SCHEMBL19917704 | 0.85 | TRPA1 (0.50) | TRPA1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL16894105 | 0.84 | KDM4E (0.48) | TRPA1MAPTKMT2AALDH1A1BMP1 | |
| SCHEMBL19917754 | 0.83 | MAPT (0.42) | TRPA1RXRARXRBRXRGTP53 | |
| SCHEMBL19917764 | 0.81 | CASR (0.39) | TRPA1HPGDMEN1KMT2A | |
| SCHEMBL16894117 | 0.81 | TRPA1 (0.53) | TRPA1BMP1 | |
| SCHEMBL16894225 | 0.81 | TRPA1 (0.53) | TRPA1TP53GAAKMT2AALDH1A1 | |
| SCHEMBL19917765 | 0.81 | TRPA1 (0.47) | TRPA1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |