Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917688 | 0.90 | CASR (0.38) | CASRNPC1RAB9ATRPA1PPARA | |
| SCHEMBL19917672 | 0.90 | CASR (0.42) | CASRNPC1RAB9ATRPA1PPARA | |
| SCHEMBL19917762 | 0.89 | NPC1 (0.46) | NPC1RAB9APPARALSSLMNA | |
| SCHEMBL19917704 | 0.86 | TRPA1 (0.50) | CASRNPC1RAB9ATRPA1LMNA | |
| SCHEMBL19917765 | 0.85 | TRPA1 (0.47) | TRPA1KMT2A | |
| SCHEMBL16894227 | 0.83 | TRPA1 (0.49) | TRPA1PTGER1KMT2A | |
| SCHEMBL19917766 | 0.82 | LMNA (0.44) | CASRNPC1RAB9ATRPA1PPARA | |
| SCHEMBL19917771 | 0.81 | KMT2A (0.37) | TRPA1OPRM1OPRL1HTR1ADRD2 | |
| SCHEMBL19917753 | 0.81 | TRPA1 (0.41) | TRPA1HPGDMEN1KMT2A | |
| SCHEMBL19917693 | 0.80 | CASR (0.56) | CASRTRPA1PPARAPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |