Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MARS2 | Q96GW9 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.43 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.42 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.42 |
| ▸ | RPS17 | P08708 | 1/20 | 0.42 |
| ▸ | RPSA | P08865 | 1/20 | 0.42 |
| ▸ | RPS2 | P15880 | 1/20 | 0.42 |
| ▸ | RPL35A | P18077 | 1/20 | 0.42 |
| ▸ | RPL7 | P18124 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1991793 | 1.00 | NPC1 (0.57) | NPC1ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL1681357 | 0.91 | NPC1 (0.60) | NPC1ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL16796557 | 0.91 | NPC1 (0.60) | NPC1ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL16796551 | 0.91 | NPC1 (0.60) | NPC1ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL11884279 | 0.87 | NPC1 (0.59) | NPC1ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL11742685 | 0.87 | NPC1 (0.58) | NPC1ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL9660474 | 0.82 | NPC1 (0.57) | NPC1ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL3780406 | 0.81 | ALDH1A1 (0.64) | NPC1ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL10244237 | 0.80 | NPC1 (0.66) | NPC1ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL2296310 | 0.80 | NPC1 (0.66) | NPC1ALDH1A1MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11697636-B2 | Substituted benzamides | HOFFMANN-LA ROCHE INC. (US) | 2023-07-11 | — | — | US | disclosed |
| EP-3187490-B1 | SUBSTITUTED BENZAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2022-04-06 | — | — | EP | disclosed |
| US-20210061760-A1 | SUBSTITUTED BENZAMIDES | HOFFMANN LA ROCHE (US) | 2021-03-04 | — | — | US | disclosed |
| US-20200048194-A1 | SUBSTITUTED BENZAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2020-02-13 | — | — | US | disclosed |
| EP-3187490-A1 | SUBSTITUTED BENZAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2017-07-05 | — | — | EP | disclosed |
| US-9452980-B2 | Substituted benzamides | HOFFMANN-LA ROCHE INC. (US) | 2016-09-27 | — | — | US | disclosed |
| US-20160264596-A1 | SUBSTITUTED BENZAMIDES | HOFFMANN-LA ROCHE INC. | 2016-09-15 | — | — | US | disclosed |
| EP-2516392-A1 | SUBSTITUTED BENZAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011076678-A1 | SUBSTITUTED BENZAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-30 | — | — | WO | disclosed |
| US-20110152245-A1 | SUBSTITUTED BENZAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160264596-A1 | SUBSTITUTED BENZAMIDES | TAAR1, TAAR5, NPY1R | NPC1 937/4885ALDH1A1 440/4885MEN1 1920/4885 |
| US-20210061760-A1 | SUBSTITUTED BENZAMIDES | TAAR1, TAAR5, NPY1R | NPC1 937/4885ALDH1A1 440/4885MEN1 1920/4885 |
| US-20110152245-A1 | SUBSTITUTED BENZAMIDES | TAAR1, TAAR5, NPY1R | NPC1 937/4885ALDH1A1 440/4885MEN1 1920/4885 |
| US-20200048194-A1 | SUBSTITUTED BENZAMIDES | TAAR1, TAAR5, NPY1R | NPC1 937/4885ALDH1A1 440/4885MEN1 1920/4885 |
| US-11697636-B2 | Substituted benzamides | TAAR1, TAAR5, NPY1R | NPC1 937/4885ALDH1A1 440/4885MEN1 1920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.