Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21760485 | 0.80 | POLB (0.33) | POLBL3MBTL1SLC10A1 | |
| SCHEMBL19900826 | 0.78 | POLB (0.32) | POLBSLC10A1 | |
| SCHEMBL20252857 | 0.76 | POLB (0.31) | POLBSLC10A1 | |
| SCHEMBL19900638 | 0.75 | SLC10A1 (0.39) | POLBSLC10A1 | |
| SCHEMBL24108657 | 0.74 | POLB (0.33) | POLBSLC10A1 | |
| SCHEMBL23369615 | 0.72 | THRB (0.30) | — | |
| SCHEMBL16699893 | 0.66 | CYP2C19 (0.32) | — | |
| SCHEMBL20134119 | 0.65 | CYP2C9 (0.33) | — | |
| SCHEMBL19900829 | 0.65 | — | — | |
| SCHEMBL19920693 | 0.64 | PKM (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504212-B1 | SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF | GILEAD SCIENCES INC (US) | 2021-05-19 | — | — | EP | disclosed |
| WO-2018039531-A1 | SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2018-03-01 | — | — | WO | disclosed |