Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 2/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22730041 | 0.91 | IRAK4 (0.45) | IRAK4DCLK1LRRK2EGFRERBB3 | |
| SCHEMBL19921070 | 0.87 | STAT6 (0.43) | IRAK4DCLK1LRRK2EGFRERBB3 | |
| SCHEMBL19921159 | 0.84 | PTK2 (0.58) | IRAK4DCLK1LRRK2EGFRPTK2 | |
| SCHEMBL21100193 | 0.83 | IRAK4 (0.59) | IRAK4LRRK2EGFRERBB3PLK1 | |
| SCHEMBL19921167 | 0.83 | PTK2 (0.51) | IRAK4DCLK1LRRK2EGFRPTK2 | |
| SCHEMBL19921085 | 0.82 | PTK2 (0.56) | EGFRPTK2 | |
| SCHEMBL19921150 | 0.82 | PLK1 (0.46) | IRAK4DCLK1LRRK2EGFRPTK2 | |
| SCHEMBL22754173 | 0.81 | IRAK4 (0.35) | IRAK4 | |
| SCHEMBL19921135 | 0.81 | CCNK (0.50) | EGFRPTK2CCNA2CDK2CCNK | |
| SCHEMBL19921084 | 0.80 | IRAK4 (0.34) | IRAK4DCLK1LRRK2PTK2STAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-B1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | UNIV XIAMEN (CN) | 2020-12-09 | — | — | EP | claimed |