Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 7/20 | 0.51 |
| ▸ | JAK2 | O60674 | 6/20 | 0.51 |
| ▸ | JAK3 | P52333 | 6/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | NEK2 | P51955 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | TTK | P33981 | 2/20 | 0.44 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | FES | P07332 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19921159 | 0.92 | PTK2 (0.58) | PTK2JAK2JAK3AXLNEK2 | |
| SCHEMBL19921112 | 0.90 | PTK2 (0.62) | PTK2JAK2JAK3AXLNEK2 | |
| SCHEMBL19921166 | 0.88 | STAT6 (0.53) | PTK2JAK2JAK3DCLK1LRRK2 | |
| SCHEMBL22730041 | 0.86 | IRAK4 (0.45) | PTK2JAK2JAK3ALKDCLK1 | |
| SCHEMBL19921085 | 0.85 | PTK2 (0.56) | PTK2ALKINSRIGF1REGFR | |
| SCHEMBL19921150 | 0.85 | PLK1 (0.46) | PTK2INSRIGF1RDCLK1LRRK2 | |
| SCHEMBL19921196 | 0.84 | ALK (0.55) | PTK2JAK2JAK3AXLNEK2 | |
| SCHEMBL22730040 | 0.83 | IRAK4 (0.42) | PTK2JAK2JAK3TTKDCLK1 | |
| SCHEMBL19921089 | 0.81 | AXL (0.53) | PTK2JAK2JAK3AXLNEK2 | |
| SCHEMBL19921180 | 0.81 | ALK (0.46) | PTK2JAK2JAK3ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-B1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | UNIV XIAMEN (CN) | 2020-12-09 | — | — | EP | claimed |
| EP-3290420-A1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | Xiamen University (CN) | 2018-03-07 | — | — | EP | claimed |