Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 10/20 | 0.55 |
| ▸ | INSR | P06213 | 6/20 | 0.55 |
| ▸ | IGF1R | P08069 | 5/20 | 0.55 |
| ▸ | TTK | P33981 | 4/20 | 0.53 |
| ▸ | PLK4 | O00444 | 3/20 | 0.52 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.52 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.52 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.52 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.52 |
| ▸ | TNK1 | Q13470 | 2/20 | 0.52 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.52 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.52 |
| ▸ | DCLK2 | Q8N568 | 2/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | PI4KA | P42356 | 1/20 | 0.52 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.52 |
| ▸ | FES | P07332 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19921113 | 0.93 | TTK (0.63) | ALKINSRIGF1RTTKPLK4 | |
| SCHEMBL19921122 | 0.91 | PLK4 (0.47) | ALKINSRIGF1RTTKPLK4 | |
| SCHEMBL20546932 | 0.85 | ALK (0.65) | ALKINSRIGF1RTTKPLK4 | |
| SCHEMBL19921184 | 0.84 | ALK (0.74) | ALKINSRIGF1RTTKPLK4 | |
| SCHEMBL19921167 | 0.84 | PTK2 (0.51) | ALKINSRIGF1RTTKDCLK1 | |
| SCHEMBL19921087 | 0.83 | ALK (0.57) | ALKINSRIGF1RTTKPLK4 | |
| SCHEMBL19921071 | 0.81 | DCLK1 (0.47) | ALKINSRIGF1RTTKPLK4 | |
| SCHEMBL21099488 | 0.79 | ALK (0.73) | ALKINSRIGF1RTTKPLK4 | |
| SCHEMBL19921127 | 0.78 | ALK (0.50) | ALKINSRIGF1RTTKPLK4 | |
| SCHEMBL19921104 | 0.78 | ALK (0.78) | ALKINSRIGF1RTTKPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-B1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | UNIV XIAMEN (CN) | 2020-12-09 | — | — | EP | claimed |
| US-20180312508-A1 | PYRIMIDOPYRROLE COMPOUNDS, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USES THEREOF | XIAMEN UNIVERSITY (CN) | 2018-11-01 | — | — | US | claimed |
| EP-3290420-A1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | Xiamen University (CN) | 2018-03-07 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180312508-A1 | PYRIMIDOPYRROLE COMPOUNDS, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USES THEREOF | TPMT, DHPS, TYMP | ALK 1505/4885INSR 3191/4885IGF1R 4466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.