Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 1/20 | 0.49 |
| ▸ | PLA2G2C | Q5R387 | 2/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 9/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 7/20 | 0.44 |
| ▸ | DPP4 | P27487 | 5/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 7/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19924266 | 1.00 | DNM1 (0.49) | DNM1PLA2G2CDPP7DPP9DPP4 | |
| SCHEMBL7603289 | 0.92 | DNM1 (0.54) | DNM1PLA2G2C | |
| SCHEMBL7603286 | 0.92 | DNM1 (0.54) | DNM1PLA2G2C | |
| SCHEMBL20186644 | 0.88 | DNM1 (0.43) | DNM1DPP7DPP9DPP4SLC1A3 | |
| SCHEMBL20914941 | 0.83 | PLA2G2C (0.51) | PLA2G2CDPP7DPP9DPP4CA2 | |
| SCHEMBL1388452 | 0.83 | CA2 (0.48) | PLA2G2CDPP7DPP9DPP4CA2 | |
| SCHEMBL4856257 | 0.83 | PLA2G2C (0.56) | PLA2G2CDPP7CA2MAPK1 | |
| SCHEMBL4820679 | 0.82 | PLA2G2C (0.46) | PLA2G2CCA2MAPK1CA1ALDH1A1 | |
| SCHEMBL16762206 | 0.82 | PLA2G2C (0.46) | PLA2G2CCA2MAPK1CA1ALDH1A1 | |
| SCHEMBL5953705 | 0.82 | PLA2G2C (0.59) | PLA2G2CCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11827609-B2 | Toll like receptor modulator compounds | GILEAD SCIENCES, INC. (US) | 2023-11-28 | — | — | US | disclosed |
| EP-3507276-B1 | TOLL LIKE RECEPTOR MODULATOR COMPOUNDS | GILEAD SCIENCES INC (US) | 2021-11-03 | — | — | EP | disclosed |
| US-11124487-B2 | Toll like receptor modulator compounds | GILEAD SCIENCES, INC. (US) | 2021-09-21 | — | — | US | disclosed |
| EP-3507288-B1 | 4,6-DIAMINO-PYRIDO[3,2-D]PYRIMIDINE DERIVATIES AS TOLL LIKE RECEPTOR MODULATORS | GILEAD SCIENCES INC (US) | 2020-08-26 | — | — | EP | disclosed |
| US-10640499-B2 | Toll like receptor modulator compounds | GILEAD SCIENCES, INC. (US) | 2020-05-05 | — | — | US | disclosed |
| US-10370342-B2 | Toll like receptor modulator compounds | GILEAD SCIENCES, INC. (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180086755-A1 | TOLL LIKE RECEPTOR MODULATOR COMPOUNDS | GILEAD SCIENCES, INC. | 2018-03-29 | — | — | US | disclosed |
| US-20180065938-A1 | TOLL LIKE RECEPTOR MODULATOR COMPOUNDS | GILEAD SCIENCES, INC. | 2018-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10370342-B2 | Toll like receptor modulator compounds | TLR8, TLR3, TLR6 | DNM1 2522/4885PLA2G2C 2105/4885DPP7 713/4885 |
| US-10640499-B2 | Toll like receptor modulator compounds | TLR8, TLR3, TLR6 | DNM1 2605/4885PLA2G2C 1895/4885DPP7 798/4885 |
| US-11124487-B2 | Toll like receptor modulator compounds | TLR8, TLR3, TLR6 | DNM1 2522/4885PLA2G2C 2105/4885DPP7 713/4885 |
| US-20180086755-A1 | TOLL LIKE RECEPTOR MODULATOR COMPOUNDS | TLR8, TLR3, TLR6 | DNM1 2522/4885PLA2G2C 2105/4885DPP7 713/4885 |
| US-20180065938-A1 | TOLL LIKE RECEPTOR MODULATOR COMPOUNDS | TLR8, TLR3, TLR6 | DNM1 2522/4885PLA2G2C 2105/4885DPP7 713/4885 |
| US-11827609-B2 | Toll like receptor modulator compounds | TLR8, TLR3, TLR6 | DNM1 2522/4885PLA2G2C 2105/4885DPP7 713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.