Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | JUN | P05412 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30468618 | 1.00 | MAPT (0.56) | MAPTKDM4EALDH1A1HPGDHDAC4 | |
| SCHEMBL21843252 | 0.82 | BRD4 (0.56) | MAPTKDM4EALDH1A1BRD4L3MBTL1 | |
| SCHEMBL1451473 | 0.81 | L3MBTL1 (0.44) | MAPTKDM4EALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL14398367 | 0.79 | KDM4E (0.60) | MAPTKDM4EALDH1A1BRD4L3MBTL1 | |
| SCHEMBL26081236 | 0.77 | BRD4 (0.51) | MAPTKDM4EALDH1A1BRD4L3MBTL1 | |
| SCHEMBL750492 | 0.77 | BRD4 (0.51) | MAPTKDM4EALDH1A1HPGDBRD4 | |
| SCHEMBL18137682 | 0.76 | BRD4 (0.56) | MAPTKDM4EALDH1A1HPGDHDAC4 | |
| SCHEMBL30785815 | 0.76 | KDM4E (0.55) | MAPTKDM4EALDH1A1HPGDHDAC6 | |
| SCHEMBL3662007 | 0.76 | KDM4E (0.55) | MAPTKDM4EALDH1A1HPGDHDAC6 | |
| SCHEMBL159285 | 0.75 | BRD4 (0.50) | MAPTKDM4EALDH1A1BRD4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113651761-B | Synthesis method of bixafen precursor | 上海恩氟佳科技有限公司 | 2023-06-23 | — | — | CN | claimed |
| CN-113651761-A | Synthesis method of bipyrazinyl bacteria amine precursor | 上海恩氟佳科技有限公司 | 2021-11-16 | — | — | CN | claimed |
| CN-118908902-A | Preparation method of 3-trifluoromethyl-2-pyrazinecarboxylic acid ester compound | 山东京博农化科技股份有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-113651761-B | Synthesis method of bixafen precursor | 上海恩氟佳科技有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-113651761-B | Synthesis method of bixafen precursor | 上海恩氟佳科技有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-113891744-A | Pyridine and pyrazine derivatives for the treatment of CF, COPD and bronchiectasis | 诺华股份有限公司 | 2022-01-04 | — | — | CN | disclosed |
| CN-113651761-A | Synthesis method of bipyrazinyl bacteria amine precursor | 上海恩氟佳科技有限公司 | 2021-11-16 | — | — | CN | disclosed |
| CN-113651761-A | Synthesis method of bipyrazinyl bacteria amine precursor | 上海恩氟佳科技有限公司 | 2021-11-16 | — | — | CN | disclosed |
| US-20190256477-A1 | METHOD FOR THE PREPARATION OF 3-(TRIFLUOROMETHYL)PYRAZINE-2-CARBOXYLIC ACID ESTERS | LONZA LTD (CH) | 2019-08-22 | — | — | US | disclosed |
| EP-3472135-A1 | METHOD FOR THE PREPARATION OF 3-(TRIFLUOROMETHYL)PYRAZINE-2-CARBOXYLIC ACID ESTERS | Lonza Ltd (CH) | 2019-04-24 | — | — | EP | disclosed |
| WO-2018041853-A1 | METHOD FOR THE PREPARATION OF 3-(TRIFLUOROMETHYL)PYRAZINE-2-CARBOXYLIC ACID ESTERS | LONZA LTD (CH) | 2018-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190256477-A1 | METHOD FOR THE PREPARATION OF 3-(TRIFLUOROMETHYL)PYRAZINE-2-CARBOXYLIC ACID ESTERS | CYP4F3, HCAR3, HCAR2 | MAPT 4414/4885KDM4E 1424/4885ALDH1A1 932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.