Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.69 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | TNKS | O95271 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.49 |
| ▸ | GABRP | O00591 | 1/20 | 0.49 |
| ▸ | GABRD | O14764 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7596849 | 0.87 | PPARG (0.61) | PPARGCYP11B1CYP11B2KDM4EUSP2 | |
| SCHEMBL28422971 | 0.87 | PPARG (0.61) | PPARGCYP11B1CYP11B2KDM4EUSP2 | |
| SCHEMBL3395103 | 0.86 | PPARG (0.63) | PPARGCYP11B1CYP11B2KDM4EUSP2 | |
| SCHEMBL29802950 | 0.86 | PPARG (0.63) | PPARGCYP11B1CYP11B2KDM4EUSP2 | |
| SCHEMBL292258 | 0.83 | PPARG (0.69) | PPARGCYP11B1CYP11B2KDM4EUSP2 | |
| SCHEMBL3715533 | 0.83 | PPARG (0.69) | PPARGCYP11B1CYP11B2KDM4EUSP2 | |
| SCHEMBL30694898 | 0.83 | PPARG (0.69) | PPARGCYP11B1CYP11B2KDM4EUSP2 | |
| SCHEMBL27484451 | 0.82 | PPARG (0.68) | PPARGCYP11B1CYP11B2KDM4EUSP2 | |
| Flidersiachromone SCHEMBL5826185 | 0.81 | PPARG (1.00) | PPARGCYP11B1CYP11B2KDM4EUSP2 | |
| Flidersiachromone SCHEMBL29408800 | 0.81 | PPARG (1.00) | PPARGCYP11B1CYP11B2KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12612391-B2 | Cromolyn derivatives and uses thereof | THE GENERAL HOSPITAL CORPORATION (US) | 2026-04-28 | — | — | US | disclosed |
| US-20240082207-A1 | MACROPHAGES/MICROGLIA IN NEURO-INFLAMMATION ASSOCIATED WITH NEURODEGENERATIVE DISEASES | THE GENERAL HOSPITAL CORPORATION | 2024-03-14 | — | — | US | disclosed |
| US-20240067635-A1 | CROMOLYN DERIVATIVES AND USES THEREOF | THE GENERAL HOSPITAL CORPORATION | 2024-02-29 | — | — | US | disclosed |
| CN-116889562-A | Macrophage/microglial cell in neuroinflammation related to neurodegenerative diseases | 通用医疗公司 | 2023-10-17 | — | — | CN | disclosed |
| EP-3506894-B1 | MACROPHAGES/MICROGLIA IN NEURO-INFLAMMATION ASSOCIATED WITH NEURODEGENERATIVE DISEASES | MASSACHUSETTS GEN HOSPITAL (US) | 2023-08-23 | — | — | EP | disclosed |
| US-11679095-B2 | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases | THE GENERAL HOSPITAL CORPORATION (US) | 2023-06-20 | — | — | US | disclosed |
| CN-109922800-B | Macrophage/microglial cell in neuroinflammation related to neurodegenerative diseases | 通用医疗公司 | 2023-06-13 | — | — | CN | disclosed |
| WO-2022146914-A1 | CROMOLYN DERIVATIVES AND USES THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2022-07-07 | — | — | WO | disclosed |
| US-20220079914-A1 | MACROPHAGES/MICROGLIA IN NEURO-INFLAMMATION ASSOCIATED WITH NEURODEGENERATIVE DISEASES | THE GENERAL HOSPITAL CORPORATION | 2022-03-17 | — | — | US | disclosed |
| EP-3506894-A1 | MACROPHAGES/MICROGLIA IN NEURO-INFLAMMATION ASSOCIATED WITH NEURODEGENERATIVE DISEASES | The General Hospital Corporation (US) | 2019-07-10 | — | — | EP | disclosed |
| CN-109922800-A | Macrophages/Microglia in Neuroinflammation Associated with Neurodegenerative Diseases | 通用医疗公司 | 2019-06-21 | — | — | CN | disclosed |
| WO-2018045217-A1 | MACROPHAGES/MICROGLIA IN NEURO-INFLAMMATION ASSOCIATED WITH NEURODEGENERATIVE DISEASES | THE GENERAL HOSPITAL CORPORATION (US) | 2018-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240067635-A1 | CROMOLYN DERIVATIVES AND USES THEREOF | PRNP, HTT, CLN6 | PPARG 2167/4885CYP11B1 1594/4885CYP11B2 1717/4885 |
| US-12612391-B2 | Cromolyn derivatives and uses thereof | HTT, PRNP, PSEN1 | PPARG 3107/4885CYP11B1 2682/4885CYP11B2 2228/4885 |
| US-11679095-B2 | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases | CD68, PRNP, HTT | PPARG 833/4885CYP11B1 3114/4885CYP11B2 3394/4885 |
| US-20220079914-A1 | MACROPHAGES/MICROGLIA IN NEURO-INFLAMMATION ASSOCIATED WITH NEURODEGENERATIVE DISEASES | CD68, PRNP, HTT | PPARG 833/4885CYP11B1 3114/4885CYP11B2 3394/4885 |
| US-20240082207-A1 | MACROPHAGES/MICROGLIA IN NEURO-INFLAMMATION ASSOCIATED WITH NEURODEGENERATIVE DISEASES | CD68, PRNP, HTT | PPARG 833/4885CYP11B1 3114/4885CYP11B2 3394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.