SCHEMBL27484451

SCHEMBL27484451

O=C(O)CCc1cc(=O)c2ccccc2o1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 3/20 0.68
KDM4E B2RXH2 1/20 0.55
USP2 O75604 1/20 0.55
CSNK2A2 P19784 1/20 0.55
PTGS1 P23219 1/20 0.55
CSNK2B P67870 1/20 0.55
CSNK2A1 P68400 1/20 0.55
CSNK2A3 Q8NEV1 1/20 0.55
CYP11B1 P15538 2/20 0.51
CYP11B2 P19099 2/20 0.51
SIGMAR1 Q99720 2/20 0.51
LMNA P02545 1/20 0.50
TNKS O95271 2/20 0.49
GABRP O00591 1/20 0.49
GABRD O14764 1/20 0.49
NPC1 O15118 1/20 0.49
CA12 O43570 1/20 0.49
CA1 P00915 1/20 0.49
CA2 P00918 1/20 0.49
TP53 P04637 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7044128 0.84 PPARG (0.62) PPARGKDM4EUSP2CSNK2A2PTGS1
SCHEMBL19925815 0.82 PPARG (0.69) PPARGKDM4EUSP2CSNK2A2PTGS1
SCHEMBL28442733 0.82 PPARG (0.60) PPARGKDM4EUSP2CSNK2A2PTGS1
Flidersiachromone SCHEMBL29408800 0.81 PPARG (1.00) PPARGKDM4EUSP2CSNK2A2PTGS1
Flidersiachromone SCHEMBL5826185 0.81 PPARG (1.00) PPARGKDM4EUSP2CSNK2A2PTGS1
SCHEMBL27820335 0.81 TNKS (0.50) PPARGCYP11B1CYP11B2TNKSGABRP
SCHEMBL30694898 0.79 PPARG (0.69) PPARGKDM4EUSP2CSNK2A2PTGS1
SCHEMBL292258 0.79 PPARG (0.69) PPARGKDM4EUSP2CSNK2A2PTGS1
SCHEMBL3715533 0.79 PPARG (0.69) PPARGKDM4EUSP2CSNK2A2PTGS1
SCHEMBL7248298 0.79 LOXL2 (0.53) KDM4EPTGS1LMNANPC1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1182129-C Benzopyran derivatives having leukotriene-antagonistic action ������ʵ���ҹ�˾ 2004-12-29 CN disclosed
CN-1214048-A Benzopyran derivatives having leukotriene-antagonistic action LABROATORIOS MENARINI S A (ES) 1999-04-14 CN disclosed