SCHEMBL19927242

SCHEMBL19927242

CC(C)(C)[Si](C)(C)O[C@@H]1[C@H](/N=C/c2ccccc2)[C@@H](CN=[N+]=[N-])O[C@H]1n1cnc2c(NC(=O)c3ccccc3)ncnc21

nearest known ligand 0.47

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ PRMT6 Q96LA8 1/20 0.45
▸ P2RY12 Q9H244 14/20 0.41
▸ P2RY2 P41231 1/20 0.39
▸ P2RY1 P47900 1/20 0.39
▸ P2RY6 Q15077 1/20 0.39
▸ AHCY P23526 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19927246 1.00 PRMT6 (0.45) PRMT6P2RY12P2RY2P2RY1P2RY6
SCHEMBL19146386 0.91 PRMT6 (0.47) PRMT6P2RY12
SCHEMBL22206837 0.90 PRMT6 (0.49) PRMT6P2RY12P2RY2P2RY1P2RY6
SCHEMBL30445813 0.90 PRMT6 (0.49) PRMT6P2RY12P2RY2P2RY1P2RY6
SCHEMBL19927301 0.89 PRMT6 (0.46) PRMT6P2RY12P2RY2P2RY1P2RY6
SCHEMBL19927469 0.88 PRMT6 (0.49) PRMT6P2RY12P2RY2P2RY1P2RY6
SCHEMBL19927404 0.85 AHCY (0.53) P2RY12AHCY
SCHEMBL19927403 0.85 AHCY (0.53) P2RY12AHCY
SCHEMBL25496498 0.84 PRMT6 (0.48) PRMT6P2RY12P2RY2P2RY1P2RY6
SCHEMBL25496516 0.84 PRMT6 (0.48) PRMT6P2RY12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190345191-A1 CYCLIC DINUCLEOTIDE ANALOGS FOR TREATING CONDITIONS ASSOCIATED WITH STING (STIMULATOR OF INTERFERON GENES) ACTIVITY INNATE TUMOR IMMUNITY INC (US) 2019-11-14 — — US disclosed
WO-2018045204-A1 CYCLIC DINUCLEOTIDE ANALOGS FOR TREATING CONDITIONS ASSOCIATED WITH STING (STIMULATOR OF INTERFERON GENES) ACTIVITY IFM THERAPEUTICS, INC (US) 2018-03-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190345191-A1 CYCLIC DINUCLEOTIDE ANALOGS FOR TREATING CONDITIONS ASSOCIATED WITH STING (STIMULATOR OF INTERFERON GENES) ACTIVITY STING1, CGAS, IRF3 PRMT6 3041/4885P2RY12 235/4885P2RY2 142/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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