Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2C | Q5R387 | 2/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.41 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RRM1 | P23921 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.40 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21389789 | 1.00 | PLA2G2C (0.46) | PLA2G2CTHRATHRBGNAI3GNAO1 | |
| SCHEMBL28496139 | 0.82 | LPAR3 (0.49) | PLA2G2A | |
| SCHEMBL11606057 | 0.76 | PLA2G2C (0.64) | PLA2G2CGPR84FFAR1ZDHHC7PLA2G2A | |
| SCHEMBL19271824 | 0.76 | PLA2G2C (0.64) | PLA2G2CGPR84FFAR1ZDHHC7PLA2G2A | |
| SCHEMBL19271786 | 0.76 | PLA2G2C (0.64) | PLA2G2CGPR84FFAR1ZDHHC7PLA2G2A | |
| SCHEMBL6940595 | 0.76 | PLA2G2C (0.64) | PLA2G2CGPR84FFAR1ZDHHC7PLA2G2A | |
| SCHEMBL20459227 | 0.76 | PLA2G2C (0.56) | PLA2G2CGPR84FFAR1ZDHHC7MAPT | |
| SCHEMBL5012513 | 0.76 | PLA2G2C (0.56) | PLA2G2CGPR84FFAR1ZDHHC7MAPT | |
| SCHEMBL20459159 | 0.76 | PLA2G2C (0.56) | PLA2G2CGPR84FFAR1ZDHHC7MAPT | |
| SCHEMBL9097264 | 0.76 | PLA2G2C (0.56) | PLA2G2CGPR84FFAR1ZDHHC7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10723753-B2 | Ras inhibitors and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-07-28 | — | — | US | disclosed |
| US-20200199102-A1 | COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF | Revolution Medicines, Inc. | 2020-06-25 | — | — | US | disclosed |
| US-20190112305-A1 | BONE MARROW ON X CHROMOSOME KINASE (BMX) INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-04-18 | — | — | US | disclosed |
| US-10000483-B2 | Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-06-19 | — | — | US | disclosed |
| US-9908872-B2 | Methods to treat lymphoplasmacytic lymphoma | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10000483-B2 | Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof | BMX, MELK, TEC | PLA2G2C 1754/4885THRA 1839/4885THRB 1175/4885 |
| US-10723753-B2 | Ras inhibitors and uses thereof | KRAS, NRAS, RASGRP1 | PLA2G2C 306/4885THRA 3631/4885THRB 2872/4885 |
| US-20190112305-A1 | BONE MARROW ON X CHROMOSOME KINASE (BMX) INHIBITORS AND USES THEREOF | BMX, MELK, TEC | PLA2G2C 1754/4885THRA 1839/4885THRB 1175/4885 |
| US-20200199102-A1 | COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF | PIN1, FKBP14, FKBP2 | PLA2G2C 2847/4885THRA 4414/4885THRB 3929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.