Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ4 | P56696 | 3/20 | 0.41 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | GLS | O94925 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19961013 | 0.85 | KCNQ4 (0.42) | KCNQ4KCNQ5LMNAHDAC1HDAC6 | |
| SCHEMBL20080090 | 0.84 | KCNQ4 (0.43) | KCNQ4KCNQ5LMNAHRH3CYP17A1 | |
| SCHEMBL20080089 | 0.71 | PPARG (0.48) | LMNA | |
| SCHEMBL19966996 | 0.71 | MAPT (0.44) | KCNQ4KCNQ5 | |
| SCHEMBL23093142 | 0.71 | SMN1; SMN2 (0.47) | KCNQ4KCNQ5LMNACNR2 | |
| SCHEMBL23093086 | 0.71 | SMN1; SMN2 (0.43) | KCNQ4KCNQ5CYP17A1 | |
| SCHEMBL19930251 | 0.71 | PPARA (0.44) | KCNQ4KCNQ5LMNACNR2 | |
| SCHEMBL23093133 | 0.71 | CNR2 (0.43) | KCNQ4KCNQ5LMNACYP17A1CNR2 | |
| SCHEMBL6033976 | 0.71 | CYP17A1 (0.42) | LMNACYP17A1MAPK14HDAC1GLS | |
| SCHEMBL23092969 | 0.70 | SMN1; SMN2 (0.46) | KCNQ4KCNQ5CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290419-A1 | FUSED-RING OR TRICYCLIC ARYL PYRIMIDINE COMPOUND USED AS KINASE INHIBITOR | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-03-07 | — | — | EP | disclosed |