Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ4 | P56696 | 3/20 | 0.43 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23093133 | 0.88 | CNR2 (0.43) | KCNQ4KCNQ5LMNACNR2CYP17A1 | |
| SCHEMBL19961013 | 0.85 | KCNQ4 (0.42) | KCNQ4KCNQ5LMNAPPARGPPARA | |
| SCHEMBL19930252 | 0.84 | KCNQ4 (0.41) | KCNQ4KCNQ5LMNAMAPK14CNR2 | |
| SCHEMBL19930245 | 0.81 | KCNQ4 (0.40) | KCNQ4KCNQ5MAPK14CNR2CYP17A1 | |
| SCHEMBL24253781 | 0.75 | NQO2 (0.45) | KCNQ4KCNQ5LMNACNR2CYP17A1 | |
| SCHEMBL19930251 | 0.75 | PPARA (0.44) | KCNQ4KCNQ5LMNACNR2PPARA | |
| SCHEMBL23093142 | 0.75 | SMN1; SMN2 (0.47) | KCNQ4KCNQ5LMNACNR2PPARA | |
| SCHEMBL23092969 | 0.74 | SMN1; SMN2 (0.46) | KCNQ4KCNQ5CNR2PPARGPPARA | |
| SCHEMBL21734883 | 0.74 | IDO1 (0.44) | — | |
| SCHEMBL21442757 | 0.74 | KCNQ4 (0.49) | KCNQ4KCNQ5CNR2CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290419-B1 | FUSED-RING OR TRICYCLIC ARYL PYRIMIDINE COMPOUND USED AS KINASE INHIBITOR | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2019-08-07 | — | — | EP | disclosed |
| EP-3312179-A1 | FUSED-RING OR TRICYCLIC ARYL PYRIMIDINE COMPOUND USED AS KINASE INHIBITOR | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-04-25 | — | — | EP | disclosed |