Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 10/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16649995 | 0.83 | BRD4 (0.67) | BRD4ADORA3ADORA2AADORA1KDM4E | |
| SCHEMBL21994131 | 0.82 | BRD4 (0.45) | BRD4ADORA3ADORA2AADORA1KDM4E | |
| SCHEMBL19930682 | 0.76 | BRD4 (0.53) | BRD4 | |
| SCHEMBL19930676 | 0.74 | BRD4 (0.60) | BRD4KMT2A | |
| SCHEMBL19930835 | 0.74 | BRD4 (0.71) | BRD4SMN1; SMN2 | |
| SCHEMBL19931487 | 0.72 | BRD4 (0.73) | BRD4 | |
| SCHEMBL19930751 | 0.70 | BRD4 (0.73) | BRD4 | |
| SCHEMBL19931457 | 0.67 | BACE1 (0.47) | BRD4ADORA3ADORA2AADORA1 | |
| SCHEMBL25043369 | 0.67 | BRD4 (0.33) | BRD4KDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL19930655 | 0.66 | BRD4 (0.40) | BRD4ADORA3ADORA2AADORA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3640241-A1 | BROMODOMAIN INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2020-04-22 | — | — | EP | disclosed |
| EP-3290407-A1 | BROMODOMAIN INHIBITORS | Celgene Quanticel Research, Inc (US) | 2018-03-07 | — | — | EP | disclosed |