Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 14/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19931012 | 0.76 | BRD4 (0.37) | BRD4 | |
| SCHEMBL25043210 | 0.71 | BRD4 (0.70) | BRD4 | |
| SCHEMBL19931105 | 0.70 | BRD4 (0.35) | BRD4PDE10A | |
| SCHEMBL19930988 | 0.70 | PDE4B (0.30) | — | |
| SCHEMBL20118620 | 0.69 | BRD4 (0.37) | BRD4PDE10AHTR2AHTR2CHTR2B | |
| SCHEMBL21915864 | 0.69 | BRD4 (0.68) | BRD4 | |
| SCHEMBL19931061 | 0.68 | BRD4 (0.47) | BRD4 | |
| SCHEMBL25043121 | 0.68 | BRD4 (0.34) | BRD4 | |
| SCHEMBL19931095 | 0.68 | RIPK1 (0.38) | HTR2AHTR2CHTR2B | |
| SCHEMBL19930879 | 0.68 | PTGER1 (0.34) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3640241-A1 | BROMODOMAIN INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2020-04-22 | — | — | EP | disclosed |
| EP-3290407-A1 | BROMODOMAIN INHIBITORS | Celgene Quanticel Research, Inc (US) | 2018-03-07 | — | — | EP | disclosed |