Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 2/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.49 |
| ▸ | BRD4 | O60885 | 10/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19930866 | 0.93 | CDK5 (0.47) | CDK5CDK5R1BRD4 | |
| SCHEMBL16650386 | 0.83 | BRD4 (0.43) | BRD4MEN1USP2ALDH1A1LMNA | |
| SCHEMBL29848814 | 0.83 | BRD4 (0.43) | BRD4MEN1USP2ALDH1A1LMNA | |
| SCHEMBL29848819 | 0.83 | BRD4 (0.43) | BRD4MEN1USP2ALDH1A1LMNA | |
| SCHEMBL16650709 | 0.80 | BRD4 (0.49) | BRD4MEN1USP2ALDH1A1LMNA | |
| SCHEMBL29848858 | 0.80 | BRD4 (0.49) | BRD4MEN1USP2ALDH1A1LMNA | |
| SCHEMBL19930783 | 0.80 | MEN1 (0.43) | BRD4MEN1USP2ALDH1A1LMNA | |
| SCHEMBL29848742 | 0.77 | BRD4 (0.41) | BRD4 | |
| SCHEMBL16650977 | 0.77 | BRD4 (0.41) | BRD4 | |
| SCHEMBL19930665 | 0.74 | BRD4 (0.46) | CDK5CDK5R1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3640241-A1 | BROMODOMAIN INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2020-04-22 | — | — | EP | disclosed |
| EP-3290407-A1 | BROMODOMAIN INHIBITORS | Celgene Quanticel Research, Inc (US) | 2018-03-07 | — | — | EP | disclosed |