Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 8/20 | 0.55 |
| ▸ | HPN | P05981 | 8/20 | 0.55 |
| ▸ | ST14 | Q9Y5Y6 | 8/20 | 0.55 |
| ▸ | F2 | P00734 | 7/20 | 0.55 |
| ▸ | HGFAC | Q04756 | 6/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.50 |
| ▸ | F12 | P00748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8257555 | 0.82 | F2 (0.47) | TMPRSS2HPNST14F2HGFAC | |
| SCHEMBL8253497 | 0.82 | F2 (0.47) | TMPRSS2HPNST14F2HGFAC | |
| SCHEMBL8260491 | 0.82 | F2 (0.47) | TMPRSS2HPNST14F2HGFAC | |
| SCHEMBL12214881 | 0.82 | F2 (0.47) | TMPRSS2HPNST14F2HGFAC | |
| SCHEMBL8257829 | 0.82 | F2 (0.47) | TMPRSS2HPNST14F2HGFAC | |
| SCHEMBL12214923 | 0.81 | HDAC3 (0.48) | TMPRSS2HPNST14F2HGFAC | |
| SCHEMBL31593090 | 0.80 | HPN (0.84) | TMPRSS2HPNST14F2HGFAC | |
| SCHEMBL31593107 | 0.76 | HPN (0.85) | TMPRSS2HPNST14F2HGFAC | |
| SCHEMBL22850400 | 0.75 | HPN (0.84) | TMPRSS2HPNST14F2HGFAC | |
| SCHEMBL31593138 | 0.75 | HPN (0.84) | TMPRSS2HPNST14F2HGFAC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220169676-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | WASHINGTON UNIVERSITY (US) | 2022-06-02 | — | — | US | disclosed |
| US-11130780-B2 | Inhibitors of growth factor activation enzymes | WASHINGTON UNIVERSITY (US) | 2021-09-28 | — | — | US | disclosed |
| US-20180066015-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | WASHINGTON UNIVERSITY (US) | 2018-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11130780-B2 | Inhibitors of growth factor activation enzymes | HDGF, MMP7, HGF | TMPRSS2 70/4885HPN 7/4885ST14 106/4885 |
| US-20220169676-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | HDGF, MMP7, HGF | TMPRSS2 70/4885HPN 7/4885ST14 106/4885 |
| US-20180066015-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | HDGF, MMP7, HGF | TMPRSS2 70/4885HPN 7/4885ST14 106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.