Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.40 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22745205 | 0.88 | RIPK1 (0.45) | OPRD1KDM1ANR1H2NR1H3UCHL1 | |
| SCHEMBL20595718 | 0.82 | CYP2D6 (0.54) | OPRD1KDM1AMEN1KMT2ALMNA | |
| SCHEMBL6536075 | 0.82 | CYP2D6 (0.54) | OPRD1KDM1AMEN1KMT2ALMNA | |
| SCHEMBL25969912 | 0.82 | CYP2D6 (0.54) | OPRD1KDM1AMEN1KMT2ALMNA | |
| SCHEMBL25969915 | 0.82 | CYP2D6 (0.54) | OPRD1KDM1AMEN1KMT2ALMNA | |
| SCHEMBL6535534 | 0.81 | OPRD1 (0.45) | OPRD1KDM1AUCHL1MEN1KMT2A | |
| SCHEMBL1584144 | 0.78 | OPRD1 (0.45) | OPRD1KDM1AUCHL1MEN1KMT2A | |
| SCHEMBL25969813 | 0.75 | ATM (0.45) | OPRD1KDM1AMEN1KMT2AKLK7 | |
| SCHEMBL20595798 | 0.74 | CYP2D6 (0.50) | NR1H2NR1H3LMNATSHR | |
| SCHEMBL6012057 | 0.74 | ATM (0.44) | OPRD1KDM1AMEN1KMT2AKLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018042303-A1 | FUSED TRICYCLIC PYRIDAZINONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2018-03-08 | — | — | WO | disclosed |