Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20595718 | 0.87 | CYP2D6 (0.54) | OPRD1KDM1AMEN1KMT2ALMNA | |
| SCHEMBL25969915 | 0.87 | CYP2D6 (0.54) | OPRD1KDM1AMEN1KMT2ALMNA | |
| SCHEMBL6536075 | 0.87 | CYP2D6 (0.54) | OPRD1KDM1AMEN1KMT2ALMNA | |
| SCHEMBL25969912 | 0.87 | CYP2D6 (0.54) | OPRD1KDM1AMEN1KMT2ALMNA | |
| SCHEMBL1584144 | 0.83 | OPRD1 (0.45) | OPRD1KDM1AMEN1KMT2AKLK7 | |
| SCHEMBL19935201 | 0.81 | OPRD1 (0.41) | OPRD1KDM1AMEN1KMT2AKLK7 | |
| SCHEMBL22745205 | 0.81 | RIPK1 (0.45) | OPRD1KDM1AMEN1KMT2ARIPK1 | |
| SCHEMBL25969813 | 0.81 | ATM (0.45) | OPRD1KDM1AMEN1KMT2AKLK7 | |
| SCHEMBL20595798 | 0.80 | CYP2D6 (0.50) | LMNATSHRGPR119 | |
| SCHEMBL6012057 | 0.80 | ATM (0.44) | OPRD1KDM1AMEN1KMT2AKLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242081-A4 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2004-07-21 | — | — | EP | disclosed |
| EP-1242081-A1 | CASPASES AND APOPTOSIS | SmithKline Beecham Corporation (US) | 2002-09-25 | — | — | EP | disclosed |
| US-6403792-B1 | INHIBIT PRODUCTION OF CASPASE 3 AND 7 IN MAMMALS | SMITHKLINE BEECHAM CORPORATION | 2002-06-11 | — | — | US | disclosed |
| WO-2001022966-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-05 | — | — | WO | disclosed |