Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | CNR1 | P21554 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | NMT2 | O60551 | 1/20 | 0.45 |
| ▸ | NMT1 | P30419 | 1/20 | 0.45 |
| ▸ | ANPEP | P15144 | 3/20 | 0.43 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.43 |
| ▸ | DNPEP | Q9ULA0 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 3/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24341572 | 0.96 | LMNA (0.55) | LMNAPKMCNR1HPGDALDH1A1 | |
| SCHEMBL28340107 | 0.88 | LMNA (0.58) | LMNAPKMCNR1HPGDALDH1A1 | |
| SCHEMBL13328249 | 0.86 | LMNA (0.60) | LMNAPKMCNR1HPGDALDH1A1 | |
| SCHEMBL17125686 | 0.85 | CNR1 (0.69) | LMNAPKMCNR1HPGDFAAH | |
| SCHEMBL20810914 | 0.85 | LMNA (0.55) | LMNAPKMCNR1HPGDALDH1A1 | |
| SCHEMBL24383336 | 0.85 | LMNA (0.55) | LMNAPKMCNR1HPGDALDH1A1 | |
| SCHEMBL10443552 | 0.85 | LMNA (0.55) | LMNAPKMCNR1HPGDALDH1A1 | |
| SCHEMBL7257878 | 0.83 | ALDH1A1 (0.58) | LMNAPKMCNR1HPGDALDH1A1 | |
| SCHEMBL1456478 | 0.83 | CNR1 (0.68) | LMNAPKMCNR1FAAH | |
| SCHEMBL24311924 | 0.83 | LMNA (0.54) | LMNAPKMCNR1HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018044350-A1 | TARGETING LIGANDS | ARROWHEAD PHARMACEUTICALS, INC (US) | 2018-03-08 | — | — | WO | disclosed |