Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24080246 | 0.87 | MEN1 (0.43) | MAPTKMT2ASMN1; SMN2GAAHTT | |
| SCHEMBL10147452 | 0.83 | KMT2A (0.47) | MAPTKMT2ASMN1; SMN2GAAHTT | |
| SCHEMBL8903721 | 0.83 | KMT2A (0.47) | MAPTKMT2ASMN1; SMN2GAAHTT | |
| SCHEMBL12780705 | 0.81 | TRPA1 (0.48) | MAPTKMT2ASMN1; SMN2GAAHTT | |
| SCHEMBL19449734 | 0.79 | CPS1 (0.36) | MAPTKMT2ASMN1; SMN2GAAHTT | |
| SCHEMBL6815355 | 0.78 | MAPT (0.42) | MAPTKMT2ASMN1; SMN2GAAHTT | |
| SCHEMBL6815360 | 0.78 | MAPT (0.42) | MAPTKMT2ASMN1; SMN2GAAHTT | |
| SCHEMBL10685097 | 0.77 | TDP1 (0.50) | MAPTKMT2ASMN1; SMN2GAAHTT | |
| SCHEMBL19622474 | 0.76 | PTGS1 (0.46) | GAAHTTLMNATRPA1 | |
| SCHEMBL19139880 | 0.76 | CES2 (0.42) | MAPTKMT2AGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016955-B1 | PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS | RHIZEN PHARMACEUTICALS S A (CH) | 2018-03-07 | — | — | EP | disclosed |