Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 2/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10049093 | 0.77 | CRHR1 (0.38) | TLR8ALPLCRHR1CA9MAPT | |
| SCHEMBL3436157 | 0.74 | CA9 (0.48) | ALPLCA9MAPTMEN1KMT2A | |
| SCHEMBL2689279 | 0.67 | CYP2A6 (0.51) | MAPTALDH1A1 | |
| SCHEMBL11962891 | 0.66 | CYP3A4 (0.46) | TLR8GAAALPLCRHR1CA9 | |
| SCHEMBL25835823 | 0.65 | GAA (0.38) | GAAMAPTALDH1A1 | |
| SCHEMBL21236592 | 0.65 | LMNA (0.36) | TGFBR1MAPTMEN1KMT2ALMNA | |
| SCHEMBL3448871 | 0.64 | KMT2A (0.42) | TLR8GAAALPLCRHR1CA9 | |
| SCHEMBL19936669 | 0.64 | ACHE (0.40) | GAACRHR1MAPTMEN1KMT2A | |
| SCHEMBL19121993 | 0.64 | MAPT (0.39) | TLR8GAAALPLCRHR1CA9 | |
| SCHEMBL24732287 | 0.63 | CCR1 (0.64) | TLR8GAAALPLCA9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594555-B1 | HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR | ASKA PHARM CO LTD (JP) | 2018-03-07 | — | — | EP | disclosed |