Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14804789 | 0.86 | LMNA (0.56) | LMNAMAPTTP53KDM4EALDH1A1 | |
| SCHEMBL3434933 | 0.73 | LMNA (0.43) | LMNAMAPTTP53MEN1KMT2A | |
| SCHEMBL7888605 | 0.68 | MAP4K1 (0.39) | LMNAMAPTTP53MEN1KMT2A | |
| SCHEMBL420666 | 0.68 | MAPT (0.43) | LMNAMAPTTP53MEN1KMT2A | |
| SCHEMBL26526576 | 0.68 | HRH3 (0.38) | LMNAGAA | |
| SCHEMBL10176848 | 0.67 | ACHE (0.44) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10176865 | 0.66 | MAPT (0.41) | LMNAMAPTTP53MEN1KMT2A | |
| SCHEMBL10012806 | 0.65 | NOS3 (0.38) | LMNAMAPTMEN1KMT2AKDM4E | |
| SCHEMBL417415 | 0.65 | MAPT (0.45) | LMNAMAPTTP53MEN1KMT2A | |
| SCHEMBL10176758 | 0.64 | MAPT (0.44) | LMNAMAPTTP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594555-B1 | HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR | ASKA PHARM CO LTD (JP) | 2018-03-07 | — | — | EP | disclosed |