Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | NEK2 | P51955 | 1/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19936673 | 0.87 | HSP90AA1 (0.40) | ALDH1A1CRHR1TP53POLBTSHR | |
| SCHEMBL19936502 | 0.87 | KCNH2 (0.41) | — | |
| SCHEMBL19936582 | 0.84 | ALDH1A1 (0.38) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL3435083 | 0.76 | KMT2A (0.47) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL19936484 | 0.75 | ALDH1A1 (0.37) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL10049090 | 0.75 | ALDH1A1 (0.37) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL19936669 | 0.70 | ACHE (0.40) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL10330271 | 0.70 | GAA (0.53) | ALDH1A1KDM4EMAPTTSHRSMN1; SMN2 | |
| SCHEMBL19936498 | 0.69 | ALDH1A1 (0.44) | ALDH1A1KDM4EMAPTTP53POLB | |
| SCHEMBL10049017 | 0.66 | CA1 (0.41) | CREBBPCRHR1POLBTDP1BRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594555-B1 | HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR | ASKA PHARM CO LTD (JP) | 2018-03-07 | — | — | EP | disclosed |