Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 6/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19936650 | 0.87 | KMT2A (0.36) | TSHRRECQLALDH1A1CRHR1TP53 | |
| SCHEMBL19936502 | 0.86 | KCNH2 (0.41) | — | |
| SCHEMBL3435989 | 0.76 | MARS1 (0.46) | HSP90AA1HSP90AB1TSHRRECQLMAPK1 | |
| SCHEMBL19936567 | 0.76 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1MAPK1PIK3CAMAPK8 | |
| SCHEMBL10049095 | 0.76 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1TSHRRECQLMAPK1 | |
| SCHEMBL19936593 | 0.71 | MAPK1 (0.36) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL19936425 | 0.71 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1MAPK1PIK3CAMAPK8 | |
| SCHEMBL19936582 | 0.71 | ALDH1A1 (0.38) | TSHRALDH1A1CRHR1TP53POLB | |
| SCHEMBL14819771 | 0.69 | NPC1 (0.40) | TSHRMAPK1PIK3CAMAPK8MAPK9 | |
| SCHEMBL14819776 | 0.69 | CACNA1H (0.43) | MAPK1PIK3CAMAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594555-B1 | HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR | ASKA PHARM CO LTD (JP) | 2018-03-07 | — | — | EP | disclosed |