Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | GNRHR | P30968 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24240417 | 0.80 | L3MBTL1 (0.45) | KDM4EHTTPRKDCJAK3GAA | |
| SCHEMBL6712387 | 0.74 | KDM4E (0.54) | KDM4EHTTPRKDCJAK3GAA | |
| SCHEMBL6678822 | 0.73 | KDM4E (0.43) | KDM4EHTTPRKDCJAK3GAA | |
| SCHEMBL19937529 | 0.73 | USP2 (0.37) | DPP4JAK3GAAACACBSMN1; SMN2 | |
| SCHEMBL26326854 | 0.72 | MAPT (0.49) | KDM4EHTTPRKDCJAK3GAA | |
| SCHEMBL26326846 | 0.72 | MAPT (0.49) | KDM4EHTTPRKDCJAK3GAA | |
| SCHEMBL31145170 | 0.70 | KDM4E (0.57) | KDM4EHTTPRKDCMAPTKMT2A | |
| SCHEMBL15383528 | 0.70 | KDM4E (0.57) | KDM4EHTTPRKDCMAPTKMT2A | |
| SCHEMBL939817 | 0.70 | KDM4E (0.49) | KDM4EHTTPRKDCJAK3GAA | |
| SCHEMBL19937334 | 0.70 | DPP4 (0.44) | DPP4DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290427-A1 | TRIAZOLE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | Melinta Therapeutics, Inc. (US) | 2018-03-07 | — | — | EP | disclosed |