Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 1/20 | 0.57 |
| ▸ | NPM1 | P06748 | 1/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.57 |
| ▸ | MAP3K12 | Q12852 | 13/20 | 0.54 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | MET | P08581 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19937630 | 0.98 | INSR (0.57) | INSRNPM1ALKMAP3K12JAK2 | |
| SCHEMBL19937609 | 0.89 | INSR (0.54) | INSRNPM1ALKMAP3K12 | |
| SCHEMBL19937622 | 0.87 | MAP3K12 (0.52) | INSRNPM1ALKMAP3K12JAK2 | |
| SCHEMBL19937777 | 0.86 | INSR (0.54) | INSRNPM1ALKMAP3K12 | |
| SCHEMBL19937634 | 0.85 | MAP3K11 (0.52) | INSRNPM1ALKMAP3K12JAK2 | |
| SCHEMBL19937624 | 0.82 | MAP3K12 (0.54) | INSRNPM1ALKMAP3K12 | |
| SCHEMBL19937632 | 0.80 | MAP3K12 (0.54) | INSRNPM1ALKMAP3K12 | |
| SCHEMBL19937610 | 0.78 | MAP3K12 (0.51) | INSRNPM1ALKMAP3K12 | |
| SCHEMBL19937588 | 0.78 | MAP3K12 (0.47) | INSRNPM1ALKMAP3K12JAK2 | |
| SCHEMBL19937762 | 0.78 | MAP3K12 (0.52) | INSRNPM1ALKMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2945938-B1 | 3-SUBSTITUTED PYRAZOLES AND USE AS DLK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2018-03-07 | — | — | EP | disclosed |