Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 7/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.50 |
| ▸ | NPM1 | P06748 | 1/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.50 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.43 |
| ▸ | ABL1 | P00519 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | HCK | P08631 | 3/20 | 0.43 |
| ▸ | SRC | P12931 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.43 |
| ▸ | MTOR | P42345 | 3/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.43 |
| ▸ | PRKDC | P78527 | 3/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19937634 | 0.98 | MAP3K11 (0.52) | MAP3K12INSRNPM1ALKMAP3K11 | |
| SCHEMBL19937772 | 0.87 | INSR (0.57) | MAP3K12INSRNPM1ALKJAK2 | |
| SCHEMBL19937630 | 0.85 | INSR (0.57) | MAP3K12INSRNPM1ALKJAK2 | |
| SCHEMBL19937609 | 0.85 | INSR (0.54) | MAP3K12INSRNPM1ALK | |
| SCHEMBL19937624 | 0.85 | MAP3K12 (0.54) | MAP3K12INSRNPM1ALK | |
| SCHEMBL19937632 | 0.82 | MAP3K12 (0.54) | MAP3K12INSRNPM1ALK | |
| SCHEMBL19937777 | 0.82 | INSR (0.54) | MAP3K12INSRNPM1ALK | |
| SCHEMBL19937610 | 0.81 | MAP3K12 (0.51) | MAP3K12INSRNPM1ALK | |
| SCHEMBL19937643 | 0.80 | MAP3K12 (0.50) | MAP3K12INSRNPM1ALKFGFR1 | |
| SCHEMBL19937789 | 0.79 | INSR (0.42) | MAP3K12INSRNPM1ALKMAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2945938-B1 | 3-SUBSTITUTED PYRAZOLES AND USE AS DLK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2018-03-07 | — | — | EP | disclosed |