Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 19/20 | 0.54 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | NPM1 | P06748 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.48 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.45 |
| ▸ | STK16 | O75716 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.45 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19937624 | 0.98 | MAP3K12 (0.54) | MAP3K12INSRNPM1ALKMAP3K13 | |
| SCHEMBL19937634 | 0.85 | MAP3K11 (0.52) | MAP3K12INSRNPM1ALK | |
| SCHEMBL19937777 | 0.84 | INSR (0.54) | MAP3K12INSRNPM1ALK | |
| SCHEMBL19937622 | 0.82 | MAP3K12 (0.52) | MAP3K12INSRNPM1ALK | |
| SCHEMBL19937751 | 0.82 | MAP3K12 (0.53) | MAP3K12 | |
| SCHEMBL19937609 | 0.82 | INSR (0.54) | MAP3K12INSRNPM1ALK | |
| SCHEMBL19937630 | 0.82 | INSR (0.57) | MAP3K12INSRNPM1ALK | |
| SCHEMBL19937642 | 0.80 | MAP3K12 (0.55) | MAP3K12 | |
| SCHEMBL19937762 | 0.80 | MAP3K12 (0.52) | MAP3K12INSRNPM1ALK | |
| SCHEMBL19937772 | 0.80 | INSR (0.57) | MAP3K12INSRNPM1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2945938-B1 | 3-SUBSTITUTED PYRAZOLES AND USE AS DLK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2018-03-07 | — | — | EP | disclosed |