Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | UBE2N | P61088 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19937783 | 0.85 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL19937629 | 0.80 | ALDH1A1 (0.34) | SMN1; SMN2ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL19937802 | 0.80 | ALDH1A1 (0.34) | SMN1; SMN2ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL1565988 | 0.75 | KDM4E (0.53) | SMN1; SMN2ALDH1A1MAPTHTTENPP3 | |
| SCHEMBL20635675 | 0.74 | HDAC1 (0.36) | SMN1; SMN2ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL13342404 | 0.72 | HSD17B10 (0.42) | ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL8256564 | 0.71 | GSK3B (0.39) | SMN1; SMN2ALDH1A1MAPTRAB9AL3MBTL1 | |
| SCHEMBL18499385 | 0.70 | KDM4E (0.53) | SMN1; SMN2ALDH1A1MAPTHTTNPSR1 | |
| SCHEMBL20502501 | 0.66 | KDM4E (0.43) | SMN1; SMN2ALDH1A1MAPTHTTENPP3 | |
| SCHEMBL21014903 | 0.65 | NPC1 (0.31) | SMN1; SMN2MAPTRAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3268373-B1 | TRICYCLIC DLK INHIBITORS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2022-04-27 | — | — | EP | disclosed |
| EP-2945938-B1 | 3-SUBSTITUTED PYRAZOLES AND USE AS DLK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2018-03-07 | — | — | EP | disclosed |