Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 4/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8256567 | 0.76 | KIT (0.43) | SMN1; SMN2NPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL4163963 | 0.74 | PTPN11 (0.52) | GSK3BPSMB5SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL19937783 | 0.74 | ALDH1A1 (0.38) | SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL19938115 | 0.71 | SMN1; SMN2 (0.35) | SMN1; SMN2RAB9AMAPTL3MBTL1KDM4E | |
| SCHEMBL13504965 | 0.71 | CYP19A1 (0.36) | KDR | |
| SCHEMBL18902075 | 0.70 | BRD4 (0.34) | — | |
| SCHEMBL19937802 | 0.70 | ALDH1A1 (0.34) | SMN1; SMN2NPC1RAB9AMAPTKMT2A | |
| SCHEMBL19937629 | 0.70 | ALDH1A1 (0.34) | SMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL21470789 | 0.66 | MGAM (0.31) | — | |
| SCHEMBL18967243 | 0.66 | ADK (0.39) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006063167-A1 | 1H-PYRROLO[2,3-B]PYRIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 2006-06-15 | — | — | WO | disclosed |