Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 4/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL859758 | 0.90 | HSD17B10 (0.42) | HSD17B10GAAKMT2AKDM4ERAB9A | |
| SCHEMBL7613832 | 0.87 | HSP90AA1 (0.48) | HSD17B10GAAKMT2AKDM4ERAB9A | |
| SCHEMBL21518879 | 0.87 | HSD17B10 (0.43) | HSD17B10GAAKMT2AKDM4ERAB9A | |
| SCHEMBL2717847 | 0.85 | SMN1; SMN2 (0.43) | HSD17B10GAAKMT2AKDM4ERAB9A | |
| SCHEMBL31575 | 0.82 | KDM4E (0.58) | HSD17B10GAAKMT2AKDM4ERAB9A | |
| SCHEMBL29706009 | 0.81 | HSD17B10 (0.52) | HSD17B10GAAKMT2AKDM4ERAB9A | |
| SCHEMBL3333926 | 0.81 | ALDH1A1 (0.50) | HSD17B10GAAKMT2AKDM4ERAB9A | |
| SCHEMBL29706037 | 0.81 | CDC7 (0.47) | HSD17B10GAAKMT2AKDM4ERAB9A | |
| SCHEMBL2555611 | 0.81 | ALDH1A1 (0.41) | HSD17B10GAAKMT2AKDM4ERAB9A | |
| SCHEMBL5519680 | 0.81 | CDC7 (0.51) | HSD17B10KMT2AKDM4ERAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290417-A1 | 2-CHLORO-N-[2-(1,3-THIAZOL-5-YL)ETHYL]-5-(5-FLUOROPYRIMIDIN-2-YL)-BENZAMIDES AND THEIR USE AS P2X7 RECEPTOR ANTAGONISTS | AXXAM S.p.A. (IT) | 2018-03-07 | — | — | EP | disclosed |