Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RPA1 | P27694 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953793 | 0.81 | KDM4E (0.48) | SMN1; SMN2KDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL19411773 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2KDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL2012056 | 0.75 | LMNA (0.50) | SMN1; SMN2KDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL10832124 | 0.73 | PDE10A (0.50) | SMN1; SMN2KDM4EALDH1A1LMNAGAA | |
| SCHEMBL29042678 | 0.73 | PDE10A (0.46) | SMN1; SMN2KDM4EALDH1A1LMNAGAA | |
| SCHEMBL7811680 | 0.72 | KDM4E (0.70) | KDM4EALDH1A1HSD17B10LMNAGAA | |
| SCHEMBL20568605 | 0.72 | ESR1 (0.49) | SMN1; SMN2KDM4EALDH1A1HSD17B10GAA | |
| SCHEMBL20570013 | 0.72 | KDM4E (0.52) | SMN1; SMN2KDM4EALDH1A1HSD17B10GAA | |
| SCHEMBL27663766 | 0.72 | PDE10A (0.49) | SMN1; SMN2KDM4EALDH1A1LMNAGAA | |
| SCHEMBL7545210 | 0.71 | HSD17B10 (0.49) | SMN1; SMN2KDM4EALDH1A1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154944-B1 | SUBSTITUTED PYRIDINONES AS MGAT2 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-14 | — | — | EP | disclosed |