Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19411773 | 0.81 | SMN1; SMN2 (0.54) | LMNASMN1; SMN2ALDH1A1RAB9APDE4A | |
| SCHEMBL2013824 | 0.79 | LMNA (0.43) | LMNASMN1; SMN2ALDH1A1RAB9APDE4A | |
| SCHEMBL7772483 | 0.79 | LMNA (0.70) | LMNASMN1; SMN2ALDH1A1RAB9AKDM4E | |
| SCHEMBL10462709 | 0.78 | LMNA (0.59) | LMNASMN1; SMN2ALDH1A1RAB9APDE4A | |
| SCHEMBL29465028 | 0.78 | LMNA (0.48) | LMNASMN1; SMN2ALDH1A1RAB9APDE4A | |
| SCHEMBL18988628 | 0.76 | PDE10A (0.47) | LMNASMN1; SMN2ALDH1A1RAB9AKDM4E | |
| SCHEMBL1127505 | 0.76 | RPA1 (0.54) | LMNASMN1; SMN2ALDH1A1RAB9AKDM4E | |
| SCHEMBL19946291 | 0.75 | SMN1; SMN2 (0.51) | LMNASMN1; SMN2ALDH1A1KDM4EGAA | |
| SCHEMBL29042678 | 0.74 | PDE10A (0.46) | LMNASMN1; SMN2ALDH1A1RAB9AKDM4E | |
| SCHEMBL7823681 | 0.74 | KDM4E (0.51) | LMNAALDH1A1RAB9AKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513061-A1 | PYRIDONE DERIVATIVES AS NK3 ANTAGONISTS | H. Lundbeck A/S (DK) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011072691-A1 | PYRIDONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2011-06-23 | — | — | WO | disclosed |