Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19951300 | 0.87 | POLB (0.55) | POLBRECQLL3MBTL1GAAALDH1A1 | |
| SCHEMBL19951294 | 0.82 | BRD4 (0.44) | KMT2AMEN1LMNA | |
| SCHEMBL19951214 | 0.82 | CYP3A4 (0.45) | POLBRECQLL3MBTL1GAAALDH1A1 | |
| SCHEMBL19951292 | 0.75 | ALDH1A1 (0.68) | POLBNPSR1GAAALDH1A1HTT | |
| SCHEMBL19951273 | 0.70 | MEN1 (0.46) | POLBALDH1A1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL16833409 | 0.69 | MAPT (0.50) | POLBRECQLL3MBTL1GAAALDH1A1 | |
| SCHEMBL276759 | 0.68 | HDAC8 (0.59) | RECQLGAAALDH1A1HTTHPGD | |
| SCHEMBL31316890 | 0.68 | F2 (0.45) | L3MBTL1ALDH1A1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL19951248 | 0.67 | ALDH1A1 (0.48) | POLBNPSR1L3MBTL1GAAALDH1A1 | |
| SCHEMBL2426452 | 0.67 | HDAC8 (0.58) | RECQLGAAALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10357477-B2 | Anticancer compounds | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2019-07-23 | — | — | US | disclosed |
| US-20180071258-A1 | ANTICANCER COMPOUNDS | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2018-03-15 | — | — | US | disclosed |
| US-20180071258-A1 | ANTICANCER COMPOUNDS | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180071258-A1 | ANTICANCER COMPOUNDS | RB1, MCL1, TP53 | POLB 1522/4885RECQL 355/4885NPSR1 3871/4885 |
| US-10357477-B2 | Anticancer compounds | RB1, MCL1, TP53 | POLB 1522/4885RECQL 355/4885NPSR1 3871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.