Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | PLAU | P00749 | 2/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.45 |
| ▸ | ELANE | P08246 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | AOC2 | O75106 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31316911 | 0.85 | TP53 (0.54) | F2PLAUKLKB1ELANEL3MBTL1 | |
| SCHEMBL31316872 | 0.84 | L3MBTL1 (0.56) | F2PLAUKLKB1ELANEL3MBTL1 | |
| SCHEMBL31316940 | 0.84 | F2 (0.47) | F2PLAUKLKB1ELANEL3MBTL1 | |
| SCHEMBL31316899 | 0.82 | F2 (0.45) | F2PLAUKLKB1ELANEL3MBTL1 | |
| SCHEMBL31316903 | 0.79 | MEN1 (0.50) | KMT2AMEN1HDAC8HDAC6KAT6A | |
| SCHEMBL31316781 | 0.77 | ALDH1A1 (0.45) | F2PLAUKLKB1ELANEL3MBTL1 | |
| SCHEMBL31316906 | 0.75 | LMNA (0.56) | L3MBTL1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL31316916 | 0.73 | KMT2A (0.40) | F2PLAUKLKB1ELANEL3MBTL1 | |
| SCHEMBL7114840 | 0.73 | F2 (0.53) | F2PLAUKLKB1ELANEL3MBTL1 | |
| SCHEMBL31316757 | 0.72 | KEAP1 (0.41) | F2PLAUKLKB1ELANEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743453-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | Pretzel Therapeutics, Inc. (US) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025015178-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | PRETZEL THERAPEUTICS, INC. (US) | 2025-01-16 | — | — | WO | disclosed |