Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19951291 | 0.87 | POLB (0.55) | POLBRECQLALDH1A1KMT2ACYP2C9 | |
| SCHEMBL19951214 | 0.73 | CYP3A4 (0.45) | POLBRECQLALDH1A1KMT2ACYP2C9 | |
| SCHEMBL20327120 | 0.71 | LOXL2 (0.44) | POLBALDH1A1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL16833409 | 0.69 | MAPT (0.50) | POLBRECQLALDH1A1KMT2ACYP2C9 | |
| SCHEMBL19951294 | 0.68 | BRD4 (0.44) | KMT2ALMNAMEN1 | |
| SCHEMBL84441 | 0.68 | TSHR (0.53) | POLBALDH1A1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL31316911 | 0.68 | TP53 (0.54) | ALDH1A1KMT2ACYP2C19GAAMEN1 | |
| SCHEMBL19951243 | 0.67 | ALDH1A1 (0.58) | ALDH1A1KMT2AHTTGAALMNA | |
| SCHEMBL8418961 | 0.67 | SLC7A5 (0.47) | POLBKMT2AMEN1RAB9AMAPT | |
| SCHEMBL698948 | 0.67 | TSHR (0.52) | POLBALDH1A1KMT2ACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10357477-B2 | Anticancer compounds | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2019-07-23 | — | — | US | disclosed |
| US-20180071258-A1 | ANTICANCER COMPOUNDS | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2018-03-15 | — | — | US | disclosed |
| US-20180071258-A1 | ANTICANCER COMPOUNDS | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180071258-A1 | ANTICANCER COMPOUNDS | RB1, MCL1, TP53 | POLB 1522/4885RECQL 355/4885ALDH1A1 757/4885 |
| US-10357477-B2 | Anticancer compounds | RB1, MCL1, TP53 | POLB 1522/4885RECQL 355/4885ALDH1A1 757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.