Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 17/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953004 | 0.87 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL21447166 | 0.80 | CRHR1 (0.55) | CRHR1 | |
| SCHEMBL21447452 | 0.76 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL20573505 | 0.74 | CRHR1 (0.68) | CRHR1 | |
| SCHEMBL5844690 | 0.72 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL25282101 | 0.72 | CRHR1 (0.41) | CRHR1TAS1R3TAS1R1 | |
| SCHEMBL19952797 | 0.71 | L3MBTL1 (0.48) | L3MBTL1 | |
| SCHEMBL21447121 | 0.71 | CRHR1 (0.36) | CRHR1 | |
| SCHEMBL5844100 | 0.70 | CRHR1 (0.64) | CRHR1 | |
| SCHEMBL7214597 | 0.70 | CRHR1 (0.55) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3510029-B1 | ALLOSTERIC CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1 (CRFR1) ANTAGONISTS THAT DECREASE P-TAU AND IMPROVE COGNITION | UNIV CALIFORNIA (US) | 2025-11-05 | — | — | EP | disclosed |
| CN-109906222-B | Allosteric corticotropin releasing factor receptor 1 (CRFR 1) antagonists that reduce P-TAU and improve cognition | 加利福尼亚大学董事会 | 2023-08-01 | — | — | CN | disclosed |
| US-11077108-B2 | Allosteric corticotropin-releasing factor receptor 1 (CRFR1) antagonists that decrease p-tau and improve cognition | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-08-03 | — | — | US | disclosed |
| US-11077108-B2 | Allosteric corticotropin-releasing factor receptor 1 (CRFR1) antagonists that decrease p-tau and improve cognition | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-08-03 | — | — | US | disclosed |
| US-20190307747-A1 | ALLOSTERIC CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1 (CRFR1) ANTAGONISTS THAT DECREASE P-TAU AND IMPROVE COGNITION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-10-10 | — | — | US | disclosed |
| US-20190307747-A1 | ALLOSTERIC CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1 (CRFR1) ANTAGONISTS THAT DECREASE P-TAU AND IMPROVE COGNITION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-10-10 | — | — | US | disclosed |
| EP-3510029-A1 | ALLOSTERIC CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1 (CRFR1) ANTAGONISTS THAT DECREASE P-TAU AND IMPROVE COGNITION | The Regents of The University of California (US) | 2019-07-17 | — | — | EP | disclosed |
| WO-2018048953-A1 | ALLOSTERIC CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1 (CRFR1) ANTAGONISTS THAT DECREASE P-TAU AND IMPROVE COGNITION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11077108-B2 | Allosteric corticotropin-releasing factor receptor 1 (CRFR1) antagonists that decrease p-tau and improve cognition | CRHR1, CRH, CRHR2 | CRHR1 1/4885TAS1R3 701/4885TAS1R1 621/4885 |
| US-20190307747-A1 | ALLOSTERIC CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1 (CRFR1) ANTAGONISTS THAT DECREASE P-TAU AND IMPROVE COGNITION | CRHR1, CRH, CRHR2 | CRHR1 1/4885TAS1R3 1017/4885TAS1R1 887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.