Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 9/20 | 1.00 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL19953228 | 0.91 | LOXL2 (0.82) | LOXL2HSD17B1CDK5CDK5R1PRMT5 | |
| SCHEMBL19953274 | 0.79 | LOXL2 (0.65) | LOXL2CYP11B1CYP11B2IDO1 | |
| SCHEMBL19953230 | 0.78 | LOXL2 (0.63) | LOXL2CYP11B1CYP11B2 | |
| SCHEMBL19953229 | 0.75 | LOXL2 (0.60) | LOXL2CDK5CDK5R1PRMT5WDR77 | |
| SCHEMBL19953219 | 0.74 | LOXL2 (0.60) | LOXL2PRMT5WDR77 | |
| SCHEMBL19953414 | 0.73 | LOXL2 (0.57) | LOXL2IDO1 | |
| SCHEMBL19953383 | 0.72 | LOXL2 (0.56) | LOXL2PRMT5WDR77CYP11B1CYP11B2 | |
| SCHEMBL19953329 | 0.71 | LOXL2 (1.00) | LOXL2PRMT5WDR77 | |
| Hydrochloric Acid SCHEMBL19954808 | 0.71 | LOXL2 (0.55) | LOXL2PRMT5WDR77CYP11B1CYP11B2 | |
| SCHEMBL19964757 | 0.70 | LOXL2 (1.00) | LOXL2HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |