Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | F10 | P00742 | 3/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | CBX7 | O95931 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1559002 | 0.86 | MAPT (0.40) | SMN1; SMN2ALDH1A1TDP1MAPTPOLB | |
| SCHEMBL1559367 | 0.81 | TDP1 (0.43) | L3MBTL1ALDH1A1TDP1MAPTPOLB | |
| SCHEMBL1558484 | 0.77 | CDYL (0.44) | L3MBTL3L3MBTL1IRAK4SMN1; SMN2ALDH1A1 | |
| SCHEMBL1559369 | 0.76 | PKM (0.42) | KDM4ESMN1; SMN2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL18909112 | 0.73 | ACHE (0.51) | ACHEL3MBTL3L3MBTL1KDM4ECYP2C9 | |
| SCHEMBL24802129 | 0.72 | ALDH1A1 (0.49) | ACHEF10L3MBTL3L3MBTL1KDM4E | |
| SCHEMBL1557723 | 0.72 | SMN1; SMN2 (0.48) | L3MBTL1KDM4ESMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL19203542 | 0.71 | ACHE (0.50) | ACHEL3MBTL3L3MBTL1KDM4ECYP2C9 | |
| SCHEMBL3542891 | 0.69 | F10 (0.57) | ACHEF10L3MBTL3L3MBTL1IRAK4 | |
| SCHEMBL3543043 | 0.69 | F10 (0.58) | ACHEF10L3MBTL3L3MBTL1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3510030-A1 | 8-(AZETIDIN-1-YL)-[1,2,4]TRIAZOLO[1,5-A]PYRIDINYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | H. Hoffnabb-La Roche Ag (CH) | 2019-07-17 | — | — | EP | disclosed |
| WO-2018046409-A1 | 8-(AZETIDIN-1-YL)-[1,2,4]TRIAZOLO[1,5-A]PYRIDINYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2018-03-15 | — | — | WO | disclosed |