Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19960634 | 1.00 | DRD2 (0.41) | DRD2DRD3CYP11B1CYP11B2HTR2C | |
| SCHEMBL19899057 | 0.81 | DRD2 (0.39) | DRD2DRD3HTR2CHTR2BANPEP | |
| SCHEMBL19899035 | 0.81 | DRD2 (0.39) | DRD2DRD3HTR2CHTR2BANPEP | |
| SCHEMBL24992268 | 0.78 | DRD2 (0.46) | DRD2HTR2CHTR2BHTR1A | |
| SCHEMBL13948435 | 0.76 | DRD2 (0.41) | DRD2DRD3HTR2CEEDHTR1A | |
| SCHEMBL1438023 | 0.76 | MAP3K14 (0.53) | DRD2HTR2CHTR2BMAP3K14HTR1A | |
| SCHEMBL16388972 | 0.76 | DRD2 (0.41) | DRD2DRD3HTR2CEEDHTR1A | |
| SCHEMBL4643692 | 0.76 | ALDH1A1 (0.38) | ANPEP | |
| SCHEMBL17397762 | 0.76 | P2RX7 (0.37) | ANPEP | |
| SCHEMBL1150762 | 0.76 | DRD2 (0.49) | DRD2DRD3CYP11B1CYP11B2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |